Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5586497 | 0.88 | AQP1 (0.54) | AQP1MAPTMAPK1NPSR1 | |
| SCHEMBL5586510 | 0.84 | AQP1 (0.38) | AQP1MAPTMAPK1L3MBTL1CHRM1 | |
| SCHEMBL27703089 | 0.82 | AQP1 (0.44) | AQP1 | |
| SCHEMBL5583525 | 0.82 | S1PR4 (0.34) | HTR2BPDE4DMAPTMAPK1NPSR1 | |
| SCHEMBL27723664 | 0.82 | AQP1 (0.36) | AQP1MAPT | |
| SCHEMBL4763783 | 0.82 | BIRC5 (0.35) | — | |
| SCHEMBL27703157 | 0.80 | AQP1 (0.46) | AQP1 | |
| SCHEMBL4770057 | 0.79 | S1PR4 (0.37) | MAPTMAPK1NPSR1TDP1L3MBTL1 | |
| SCHEMBL4607974 | 0.78 | AQP1 (0.32) | AQP1MAPTTDP1 | |
| SCHEMBL5583498 | 0.78 | AQP1 (0.38) | AQP1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |