Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16041940 | 0.90 | KEAP1 (0.54) | MAPTKEAP1NFE2L2CXCL8CYP2C9 | |
| SCHEMBL28071595 | 0.83 | MAPT (0.50) | MAPTCYP2C9LMNAALDH1A1TDP1 | |
| SCHEMBL1154758 | 0.81 | IDO1 (0.50) | MAPTCYP2C9LMNAALDH1A1TDP1 | |
| SCHEMBL29493203 | 0.81 | IDO1 (0.50) | MAPTCYP2C9LMNAALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL3051125 | 0.80 | IDO1 (0.47) | MAPTKEAP1NFE2L2CXCL8CYP2C9 | |
| SCHEMBL2394432 | 0.80 | KEAP1 (0.53) | MAPTKEAP1NFE2L2CXCL8CYP2C9 | |
| SCHEMBL260512 | 0.80 | CHRM1 (0.57) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL29419329 | 0.80 | CHRM1 (0.57) | KEAP1NFE2L2CXCL8CYP2C9CHRM1 | |
| SCHEMBL29497752 | 0.80 | CXCL8 (0.57) | MAPTKEAP1NFE2L2CXCL8CYP2C9 | |
| SCHEMBL2578143 | 0.80 | CXCL8 (0.57) | MAPTKEAP1NFE2L2CXCL8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948630-A2 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007052023-A2 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |