Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3326310 | 0.79 | HRH3 (0.50) | HRH3EPHX2 | |
| SCHEMBL3325419 | 0.79 | HRH3 (0.50) | HRH3EPHX2 | |
| SCHEMBL3325423 | 0.79 | HRH3 (0.50) | HRH3EPHX2 | |
| SCHEMBL4608539 | 0.77 | IKZF2 (0.42) | HRH3 | |
| SCHEMBL4610113 | 0.72 | CTSS (0.45) | HRH3 | |
| SCHEMBL6634646 | 0.72 | CHRNA7 (0.64) | HRH3EPHX2CHRNA7 | |
| SCHEMBL6153633 | 0.70 | SYK (0.51) | — | |
| SCHEMBL6153631 | 0.70 | SYK (0.51) | — | |
| SCHEMBL6633015 | 0.70 | CHRNA7 (0.70) | HRH3EPHX2CHRNA7 | |
| SCHEMBL4654177 | 0.68 | CCR1 (0.49) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976840-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES AND THEIR USE AS HISTAMINE H3 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007080140-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES AND THEIR USE AS HISTAMINE H3 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-19 | — | — | WO | disclosed |