Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 7/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323650 | 0.82 | GPR119 (0.41) | GPR119HRH3BAZ2BMAPK14 | |
| SCHEMBL3323647 | 0.82 | GPR119 (0.41) | GPR119HRH3BAZ2BMAPK14 | |
| SCHEMBL3330385 | 0.82 | GPR119 (0.41) | GPR119HRH3BAZ2BMAPK14 | |
| SCHEMBL4608665 | 0.77 | HRH3 (0.46) | HRH3 | |
| SCHEMBL4610113 | 0.67 | CTSS (0.45) | HRH3 | |
| SCHEMBL5523269 | 0.64 | MEN1 (0.55) | BAZ2BMAPK14 | |
| SCHEMBL4654177 | 0.64 | CCR1 (0.49) | HRH3 | |
| SCHEMBL4962872 | 0.63 | RAB9A (0.59) | — | |
| SCHEMBL13503770 | 0.63 | ALDH1A1 (0.70) | HRH3 | |
| SCHEMBL1091777 | 0.62 | BAZ2B (0.82) | BAZ2BMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976840-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES AND THEIR USE AS HISTAMINE H3 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007080140-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES AND THEIR USE AS HISTAMINE H3 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-19 | — | — | WO | disclosed |