Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902514 | 0.87 | GRM5 (0.55) | GRM5ALDH1A1TDP1SMN1; SMN2LMNA | |
| SCHEMBL4610103 | 0.83 | GRM5 (0.59) | GRM5ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4609669 | 0.78 | GRM5 (0.56) | GRM5TDP1NPY2RTP53 | |
| SCHEMBL4608995 | 0.77 | GRM5 (0.45) | GRM5ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1904164 | 0.75 | GRM5 (0.77) | GRM5 | |
| SCHEMBL4609000 | 0.73 | SLC6A2 (0.43) | GRM5NPY2RHTR6 | |
| SCHEMBL4155422 | 0.72 | GRM5 (0.47) | GRM5ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL4713865 | 0.72 | GRM5 (0.52) | GRM5ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL4608986 | 0.71 | HRH3 (0.40) | GRM5 | |
| SCHEMBL4608127 | 0.71 | GRM5 (0.41) | GRM5ALDH1A1SMN1; SMN2LMNANPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |