Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609928 | 0.91 | TSHR (0.48) | GRM5LMNAMAPTSMN1; SMN2GFER | |
| SCHEMBL1902514 | 0.83 | GRM5 (0.55) | GRM5LMNAMAPTSMN1; SMN2GFER | |
| SCHEMBL4609669 | 0.82 | GRM5 (0.56) | GRM5TP53SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27757105 | 0.81 | GRM5 (0.56) | GRM5LMNAMAPTSMN1; SMN2GFER | |
| SCHEMBL9261218 | 0.76 | ADRA2A (0.40) | LMNAMAPTGFERALDH1A1TSHR | |
| SCHEMBL4610798 | 0.76 | GRM5 (0.54) | GRM5MAPTPOLB | |
| SCHEMBL4610277 | 0.75 | HCAR2 (0.42) | GRM5LMNAMAPTSMN1; SMN2GFER | |
| SCHEMBL4467700 | 0.73 | TSHR (0.44) | GRM5LMNAMAPTSMN1; SMN2GFER | |
| SCHEMBL27757102 | 0.73 | GRM5 (0.62) | GRM5LMNAMAPTSMN1; SMN2GFER | |
| SCHEMBL4608986 | 0.72 | HRH3 (0.40) | GRM5SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |