Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609146 | 0.91 | MAPK14 (0.57) | MAPK14SCN9AMCHR2MCHR1CNR1 | |
| SCHEMBL2443317 | 0.89 | MAPK14 (0.63) | MAPK14ALOX15TSHRSCN9AMCHR2 | |
| SCHEMBL4610566 | 0.87 | MAPK14 (0.62) | MAPK14MCHR2MCHR1NR3C1 | |
| SCHEMBL4611378 | 0.84 | MAPK14 (0.45) | MAPK14MCHR2MCHR1NR3C1MEN1 | |
| SCHEMBL4610157 | 0.80 | MAPK14 (0.46) | MAPK14SCN9AMCHR2MCHR1 | |
| SCHEMBL4611567 | 0.80 | MAPK14 (0.44) | MAPK14TSHRSCN9AMEN1KMT2A | |
| SCHEMBL2445182 | 0.79 | MAPK14 (0.73) | MAPK14SCN9AMCHR1MEN1KMT2A | |
| SCHEMBL4608950 | 0.77 | MAPK14 (0.48) | MAPK14SCN9AMCHR2MCHR1NR3C1 | |
| SCHEMBL4609151 | 0.76 | MAPK14 (0.43) | MAPK14TSHRSCN9AMCHR2MCHR1 | |
| SCHEMBL4609013 | 0.76 | MAPK14 (0.48) | MAPK14SCN9ANR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606283-B1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2008-10-08 | — | — | EP | claimed |