Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.73 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | POLR1A | O95602 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31371552 | 0.95 | MAPK14 (0.81) | MAPK14AXLMCHR1CACNA1HHIPK4 | |
| SCHEMBL2443328 | 0.95 | MAPK14 (0.81) | MAPK14AXLMCHR1CACNA1HHIPK4 | |
| SCHEMBL2443317 | 0.90 | MAPK14 (0.63) | MAPK14MCHR1SCN9AL3MBTL1MEN1 | |
| SCHEMBL5296558 | 0.88 | MAPK14 (0.62) | MAPK14MCHR1MEN1KMT2AHIPK4 | |
| SCHEMBL4609146 | 0.87 | MAPK14 (0.57) | MAPK14AXLMCHR1SCN9ACACNA1H | |
| SCHEMBL31371595 | 0.87 | MAPK14 (0.72) | MAPK14AXLMCHR1L3MBTL1KMT2A | |
| Arry-797 SCHEMBL29351662 | 0.85 | MAPK14 (1.00) | MAPK14METKDRL3MBTL1MEN1 | |
| Arry-797 SCHEMBL222635 | 0.85 | MAPK14 (1.00) | MAPK14METKDRL3MBTL1MEN1 | |
| Arry-797 SCHEMBL31046796 | 0.85 | MAPK14 (1.00) | MAPK14METKDRL3MBTL1MEN1 | |
| Arry-797 SCHEMBL29349798 | 0.85 | MAPK14 (1.00) | MAPK14METKDRL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606283-B1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2008-10-08 | — | — | EP | claimed |
| US-8017641-B2 | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-09-13 | — | — | US | disclosed |