Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445182 | 0.90 | MAPK14 (0.73) | MAPK14KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4608883 | 0.89 | MAPK14 (0.49) | MAPK14MAPTLMNAPOLBALOX15 | |
| SCHEMBL31371552 | 0.87 | MAPK14 (0.81) | MAPK14ALDH1A1MCHR1MCHR2SMN1; SMN2 | |
| SCHEMBL2443328 | 0.87 | MAPK14 (0.81) | MAPK14ALDH1A1MCHR1MCHR2SMN1; SMN2 | |
| SCHEMBL5296558 | 0.86 | MAPK14 (0.62) | MAPK14KDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL2450576 | 0.83 | MAPK14 (0.59) | MAPK14LMNAKDM4EALDH1A1MCHR1 | |
| SCHEMBL2448328 | 0.80 | MAPK14 (0.61) | MAPK14MCHR1SCN9AMCHR2 | |
| SCHEMBL2450289 | 0.80 | MAPK14 (0.57) | MAPK14MAPTLMNAALOX15TSHR | |
| SCHEMBL31371520 | 0.80 | MAPK14 (0.70) | MAPK14KDM4EALDH1A1HSD17B10MCHR1 | |
| SCHEMBL2446126 | 0.80 | MAPK14 (0.56) | MAPK14MCHR1MCHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017641-B2 | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-09-13 | — | — | US | disclosed |