SCHEMBL4608932

SCHEMBL4608932

Cc1[c]ccc(-c2cc(Cl)ccc2Cl)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2B P41595 1/20 0.36
PDE4D Q08499 1/20 0.36
TP53 P04637 3/20 0.35
AHR P35869 2/20 0.34
PTPN11 Q06124 2/20 0.34
IDO1 P14902 1/20 0.34
ALDH1A1 P00352 5/20 0.33
RXFP1 Q9HBX9 1/20 0.33
PDE2A O00408 3/20 0.33
PDE10A Q9Y233 2/20 0.33
CNR2 P34972 1/20 0.33
MAPT P10636 2/20 0.33
RAB9A P51151 1/20 0.33
DUSP3 P51452 1/20 0.33
HSD11B1 P28845 1/20 0.33
TSHR P16473 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
CYP3A4 P08684 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4430969 0.86 MAP4K4 (0.42) IDO1CYP3A4
SCHEMBL4431126 0.86 ALKBH3 (0.37) AHRCNR2
SCHEMBL4428497 0.83 HTT (0.35) AHRALDH1A1MAPT
SCHEMBL15637040 0.81 TP53 (0.38) HTR2BPDE4DTP53AHRPTPN11
SCHEMBL15636889 0.80 CYP2A6 (0.47) ALDH1A1HSD11B1KMT2A
SCHEMBL4439265 0.79 PDE2A (0.39) PDE2APDE10AHSD11B1
SCHEMBL15637152 0.79 HTR2B (0.36) HTR2BPDE4DTP53AHRPTPN11
SCHEMBL512419 0.77 ALOX5 (0.42) AHRALDH1A1RAB9ACYP3A4MEN1
SCHEMBL534233 0.75 TP53 (0.42) HTR2BPDE4DTP53AHRPTPN11
SCHEMBL27978166 0.75 HTR2B (0.37) HTR2BPDE4DTP53AHRPTPN11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008091594-A2 FUNGICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed
EP-1948649-A2 FUNGICIDAL CARBOXAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-30 EP disclosed
WO-2007014290-A2 FUNGICIDAL CARBOXAMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-02-01 WO disclosed