Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.78 |
| ▸ | MMP9 | P14780 | 13/20 | 0.78 |
| ▸ | MMP3 | P08254 | 12/20 | 0.78 |
| ▸ | MMP13 | P45452 | 12/20 | 0.78 |
| ▸ | MMP1 | P03956 | 11/20 | 0.78 |
| ▸ | MMP7 | P09237 | 11/20 | 0.78 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.78 |
| ▸ | MMP14 | P50281 | 1/20 | 0.74 |
| ▸ | MMP8 | P22894 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609258 | 1.00 | MMP2 (0.78) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL32691806 | 0.88 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL1750956 | 0.88 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL4653257 | 0.88 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7870625 | 0.87 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL8283899 | 0.87 | ADAMTS4 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL1655901 | 0.87 | ADAMTS4 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7870619 | 0.87 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL5806025 | 0.86 | MMP2 (0.60) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7406967 | 0.85 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885694-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1877373-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| WO-2006121861-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |