SCHEMBL1750956

SCHEMBL1750956

CC(C)C(NS(=O)(=O)c1ccc(-c2ccccc2)cc1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 14/20 1.00
▸ MMP3 P08254 12/20 1.00
▸ MMP13 P45452 12/20 1.00
▸ MMP1 P03956 11/20 1.00
▸ MMP7 P09237 11/20 1.00
▸ MMP9 P14780 11/20 1.00
▸ ADAMTS4 O75173 6/20 1.00
▸ MMP14 P50281 1/20 0.78
▸ MMP8 P22894 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32691806 1.00 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL4653257 1.00 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL3973093 0.90 MMP2 (0.82) MMP2MMP3MMP13MMP1MMP7
SCHEMBL21451101 0.90 MMP2 (0.82) MMP2MMP3MMP13MMP1MMP7
SCHEMBL6561375 0.90 MMP2 (0.82) MMP2MMP3MMP13MMP1MMP7
SCHEMBL16380447 0.89 MMP2 (0.81) MMP2MMP3MMP13MMP1MMP7
SCHEMBL7870619 0.89 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL8283899 0.89 ADAMTS4 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL1655901 0.89 ADAMTS4 (1.00) MMP2MMP3MMP13MMP1MMP7
SCHEMBL7870625 0.89 MMP2 (1.00) MMP2MMP3MMP13MMP1MMP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090292129-A1 PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST ABIOGEN PHARMA S.P.A. (IT) 2009-11-26 — — US claimed
EP-1986996-A2 A PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST Abiogen Pharma S.p.A. (IT) 2008-11-05 — — EP claimed
WO-2007088571-A2 A PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST ABIOGEN PHARMA S.P.A. (IT) 2007-08-09 — — WO claimed
US-9598383-B2 Reactive oxygen species-based prodrugs THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-03-21 — — US disclosed
US-20150005352-A1 REACTIVE OXYGEN SPECIES-BASED PRODRUGS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-01-01 — — US disclosed
US-7968748-B2 Process for resolving racemic mixtures and a diastereoisomeric complex of a resolving agent and an enantiomer of interest ABIOGEN PHARMA S.P.A. (IT) 2011-06-28 — — US disclosed
US-7968748-B2 Process for resolving racemic mixtures and a diastereoisomeric complex of a resolving agent and an enantiomer of interest ABIOGEN PHARMA S.P.A. (IT) 2011-06-28 — — US disclosed
US-20090292129-A1 PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST ABIOGEN PHARMA S.P.A. (IT) 2009-11-26 — — US disclosed
US-20090292129-A1 PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST ABIOGEN PHARMA S.P.A. (IT) 2009-11-26 — — US disclosed
EP-1986996-A2 A PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST Abiogen Pharma S.p.A. (IT) 2008-11-05 — — EP disclosed
WO-2007088571-A2 A PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST ABIOGEN PHARMA S.P.A. (IT) 2007-08-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150005352-A1 REACTIVE OXYGEN SPECIES-BASED PRODRUGS ROS1, NOX4, NOX1 MMP2 1413/4885MMP3 460/4885MMP13 887/4885
US-20090292129-A1 PROCESS FOR RESOLVING RACEMIC MIXTURES AND A DIASTEREOISOMERIC COMPLEX OF A RESOLVING AGENT AND AN ENANTIOMER OF INTEREST SRR, EPHX2, ALOX5 MMP2 3701/4885MMP3 3823/4885MMP13 3819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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