Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27476987 | 0.92 | RHEB (0.34) | RHEBGRIN1DHODH | |
| SCHEMBL5180853 | 0.78 | INPPL1 (0.40) | GRIN1 | |
| SCHEMBL2363622 | 0.77 | KDM4E (0.33) | — | |
| SCHEMBL8844752 | 0.73 | MAPT (0.33) | — | |
| SCHEMBL166351 | 0.72 | ALDH1A1 (0.35) | GRIN1HTT | |
| SCHEMBL1156230 | 0.71 | HTT (0.46) | GRIN1HTT | |
| SCHEMBL10778177 | 0.71 | TDP1 (0.38) | — | |
| SCHEMBL27493427 | 0.71 | KDM4E (0.33) | — | |
| Water SCHEMBL2477029 | 0.70 | ALDH1A1 (0.34) | HTT | |
| SCHEMBL7407292 | 0.70 | TDP1 (0.43) | RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976505-A1 | COMBRETASTATIN DERIVATIVES AND RELATED THERAPEUTIC METHODS | Abraxis BioScience, Inc. (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007059118-A1 | COMBRETASTATIN DERIVATIVES AND RELATED THERAPEUTIC METHODS | ABRAXIS BIOSCIENCE, INC. (US) | 2007-05-24 | — | — | WO | disclosed |