Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | CTSD | P07339 | 3/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320529 | 0.96 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL5709143 | 0.94 | NR1H4 (0.51) | NR1H4CTSDELANE | |
| SCHEMBL4847539 | 0.94 | NR1H4 (0.51) | NR1H4CTSDELANE | |
| SCHEMBL5709249 | 0.92 | NR1H4 (0.56) | NR1H4CTSDELANE | |
| SCHEMBL4782628 | 0.92 | NR1H4 (0.51) | NR1H4CTSDELANE | |
| SCHEMBL5821358 | 0.91 | NR1H4 (0.56) | NR1H4 | |
| SCHEMBL4611434 | 0.91 | NR1H4 (0.50) | NR1H4CTSDELANE | |
| SCHEMBL4846444 | 0.89 | NR1H4 (0.49) | NR1H4CTSDELANE | |
| SCHEMBL4783638 | 0.89 | NR1H4 (0.56) | NR1H4ELANE | |
| SCHEMBL4851757 | 0.89 | NR1H4 (0.48) | NR1H4CTSDELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515984-A1 | PEPTIDE DERIVATIVES COMPRISING THIAZEPINE GROUP FOR THE TREATMENT OF HYPERLIPIDEMIC CONDITIONS | Astrazeneca AB (SE) | 2005-03-23 | — | — | EP | claimed |
| WO-2003106482-A1 | PEPTIDES DERIVATIVES COMPRISING THIAZEPINE GROUP FOR THE TREATMENT OF HYPERLIPIDEMIC CONDITIONS | ASTRAZENECA AB (SE) | 2003-12-24 | — | — | WO | claimed |
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1896408-A1 | NEW 2-AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HYPERLIPIDAEMIC DISEASES | AstraZeneca AB (SE) | 2008-03-12 | — | — | EP | disclosed |
| EP-1896407-A1 | NOVEL 2-AZETIDINONE DERIVATIVES AND THEIR USE AS CHOLESTEROL ABSORPTION INHIBITORS FOR THE TREATMENT OF HYPERLIPIDAEMIA | AstraZeneca AB (SE) | 2008-03-12 | — | — | EP | disclosed |
| EP-1877373-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1851197-A2 | PHENYLAZETIDINONE DERIVATIVES | Microbia, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006137782-A1 | NOVEL 2-AZETIDINONE DERIVATIVES AND THEIR USE AS CHOLESTEROL ABSORPTION INHIBITORS FOR THE TREATMENT OF HYPERLIPIDAEMIA | ASTRAZENECA AB (SE) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006137794-A1 | NEW2-AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HYPERLIPIDAEMIC DISEASES | ASTRAZENECA AB (SE) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006121861-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006086562-A2 | PHENYLAZETIDINONE DERIVATIVES | MICROBIA, INC. (US) | 2006-08-17 | — | — | WO | disclosed |
| EP-1521742-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004005247-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |