Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636187 | 0.96 | NR1H4 (0.62) | NR1H4ELANEKMT2A | |
| SCHEMBL4847539 | 0.95 | NR1H4 (0.51) | NR1H4ELANECTSDKDM4EPKM | |
| SCHEMBL4782628 | 0.95 | NR1H4 (0.51) | NR1H4ELANECTSDKDM4EPKM | |
| SCHEMBL4611434 | 0.94 | NR1H4 (0.50) | NR1H4ELANECTSD | |
| SCHEMBL4846444 | 0.93 | NR1H4 (0.49) | NR1H4ELANECTSD | |
| SCHEMBL5709143 | 0.93 | NR1H4 (0.51) | NR1H4ELANECTSD | |
| SCHEMBL4851757 | 0.93 | NR1H4 (0.48) | NR1H4ELANECTSDMEN1KMT2A | |
| SCHEMBL4609459 | 0.92 | NR1H4 (0.50) | NR1H4ELANECTSD | |
| SCHEMBL3831828 | 0.92 | NR1H4 (0.56) | NR1H4ELANEMEN1KMT2A | |
| SCHEMBL4783638 | 0.92 | NR1H4 (0.56) | NR1H4ELANEKDM4EPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699759-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061452-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |