Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 3/20 | 0.32 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709249 | 0.95 | NR1H4 (0.56) | NR1H4ELANECTSDKDM4EPKM | |
| SCHEMBL4782628 | 0.95 | NR1H4 (0.51) | NR1H4ELANECTSDKDM4EPKM | |
| SCHEMBL4609459 | 0.94 | NR1H4 (0.50) | NR1H4ELANECTSD | |
| SCHEMBL4611434 | 0.94 | NR1H4 (0.50) | NR1H4ELANECTSDMME | |
| SCHEMBL5709143 | 0.92 | NR1H4 (0.51) | NR1H4ELANECTSD | |
| SCHEMBL4846444 | 0.92 | NR1H4 (0.49) | NR1H4ELANECTSD | |
| SCHEMBL4851757 | 0.92 | NR1H4 (0.48) | NR1H4ELANECTSD | |
| SCHEMBL6206446 | 0.92 | NR1H4 (0.55) | NR1H4SLC10A1 | |
| SCHEMBL4636187 | 0.92 | NR1H4 (0.62) | NR1H4ELANE | |
| SCHEMBL4783638 | 0.91 | NR1H4 (0.56) | NR1H4ELANEKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1699759-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| EP-1610770-A1 | USE OF AN IBAT INHIBITOR FOR THE TREATMENT OF PROPHYLAXIS OF CONSTIPATION | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2005061452-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
| EP-1521742-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | AstraZeneca AB (SE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004089350-A1 | USE OF AN IBAT INHIBITOR FOR THE TREATMENT OF PROPHYLAXIS OF CONSTIPATION | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | disclosed |
| WO-2004005247-A1 | DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |