Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773634 | 0.96 | NR1H4 (0.54) | NR1H4 | |
| SCHEMBL5709249 | 0.93 | NR1H4 (0.56) | NR1H4ELANECTSD | |
| SCHEMBL4782628 | 0.92 | NR1H4 (0.51) | NR1H4ELANECTSD | |
| SCHEMBL4847539 | 0.92 | NR1H4 (0.51) | NR1H4ELANECTSD | |
| SCHEMBL4611434 | 0.91 | NR1H4 (0.50) | NR1H4ELANECTSD | |
| SCHEMBL5709143 | 0.90 | NR1H4 (0.51) | NR1H4ELANECTSD | |
| SCHEMBL4851757 | 0.90 | NR1H4 (0.48) | NR1H4ELANECTSD | |
| SCHEMBL4609459 | 0.89 | NR1H4 (0.50) | NR1H4ELANECTSD | |
| SCHEMBL4636187 | 0.89 | NR1H4 (0.62) | NR1H4ELANE | |
| SCHEMBL4783638 | 0.89 | NR1H4 (0.56) | NR1H4ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1877067-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006116499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | MICROBIA, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| EP-1699759-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| EP-1675820-A2 | PROPIONIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF LIPID DISORDERS | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |
| EP-1638922-A1 | PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES | AstraZeneca AB (SE) | 2006-03-29 | — | — | EP | disclosed |
| EP-1610770-A1 | USE OF AN IBAT INHIBITOR FOR THE TREATMENT OF PROPHYLAXIS OF CONSTIPATION | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2005061452-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
| WO-2004113270-A2 | PROPIONIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF LIPID DISORDERS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |
| WO-2004110984-A1 | PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | WO | disclosed |
| WO-2004089350-A1 | USE OF AN IBAT INHIBITOR FOR THE TREATMENT OF PROPHYLAXIS OF CONSTIPATION | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | disclosed |