Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10402889 | 0.82 | MAPK1 (0.36) | ALDH1A1HPGDKDM4CTSHRMAPK1 | |
| SCHEMBL8957670 | 0.80 | EGLN3 (0.44) | ALDH1A1HPGDKDM4CMAPK1CYP1A2 | |
| SCHEMBL955006 | 0.77 | CYP1A2 (0.52) | ALDH1A1HPGDKDM4CTSHRMAPK1 | |
| SCHEMBL11217089 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CTSHRMAPK1 | |
| SCHEMBL11196988 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CTSHRMAPK1 | |
| SCHEMBL11710847 | 0.75 | MAPK1 (0.62) | ALDH1A1HPGDKDM4CTSHRMAPK1 | |
| SCHEMBL4142949 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CTSHRMAPK1 | |
| SCHEMBL342613 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CTSHRMAPK1 | |
| SCHEMBL829258 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CTSHRMAPK1 | |
| SCHEMBL8056548 | 0.73 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4CTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448393-B1 | DEPROTECTING CARBOXYLIC ACID GROUP, DEHALOGENATING AND SULFIDING WITH HETEROARYL-THIO SUBSTITUTED COMPOUND PRODUCING 3-THIOMETHYLCEPHEM COMPOUNDS; CHEMICAL INTERMEDIATES TO ANTIBIOTICS, SUCH AS CEFAZOLIN AND CEFTRIAXONE | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 2002-09-10 | — | — | US | claimed |
| EP-1028118-A1 | PROCESS FOR PRODUCING 3-CEPHEM COMPOUNDS | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 2000-08-16 | — | — | EP | claimed |
| EP-0300546-B1 | Process for the preparation of cephem compounds and cephalosporin derivatives | GIST BROCADES NV (NL) | 1995-08-09 | — | — | EP | claimed |
| US-4921954-A | FROM SULFOXIDE INTERMEDIATE | GIST-BROCADES N.V. (NL) | 1990-05-01 | — | — | US | claimed |
| EP-0300546-A1 | Process for the preparation of cephem compounds and cephalosporin derivatives | GIST-BROCADES N.V. (NL) | 1989-01-25 | — | — | EP | claimed |
| EP-0099580-B1 | NEW 1-OXA-1-DETHIA-CEPHALOSPORIN DERIVATIVES | MERCK & CO. INC. (US) | 1987-10-14 | — | — | EP | claimed |
| US-4661480-A | Formamido oxacephems | BEECHAM GROUP P.L.C. (GB) | 1987-04-28 | — | — | US | claimed |
| US-4578378-A | (Oxoheterocyclic carbonamido)cephem carboxylic acid derivatives | SHIONOGI & CO., LTD. (JP) | 1986-03-25 | — | — | US | claimed |
| US-4534898-A | 1-Oxa-1-dethia-cephalosporin derivatives | MERCK & CO., INC. (US) | 1985-08-13 | — | — | US | claimed |
| EP-0121499-A2 | Cephalosporins, their preparation and pharmaceutical compositions | CIBA-GEIGY AG (CH) | 1984-10-10 | — | — | EP | claimed |
| EP-0000500-B1 | CEPHALOSPRIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1982-04-28 | — | — | EP | claimed |
| EP-0049309-A1 | Cephem derivatives, process for producing thereof, and antibacterial agents comprising said compounds | Eisai Co., Ltd. (JP) | 1982-04-14 | — | — | EP | claimed |
| US-4313945-A | 7-Thiazolyl-acetamido-cephem derivatives with terminal aminocarboxylic acid grouping | CIBA-GEIGY CORPORATION (US) | 1982-02-02 | — | — | US | claimed |
| US-4285941-A | ANTIBIOTICS | EISAI CO., LTD. (JP) | 1981-08-25 | — | — | US | claimed |
| EP-0031794-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1981-07-08 | — | — | EP | claimed |
| US-4271296-A | CEPHALOSPORINS AND DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1981-06-02 | — | — | US | claimed |
| EP-0022245-A2 | Aminothiadiazolyl derivatives, process for their preparation, pharmaceutical compositions containing them;starting compounds and process for their preparation | CIBA-GEIGY AG (CH) | 1981-01-14 | — | — | EP | claimed |
| US-4229573-A | BACTERICIDES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1980-10-21 | — | — | US | claimed |
| EP-0016296-A1 | Cephalosporin derivatives, process for their preparation, compositions containing them, and intermediates and their preparation | CIBA-GEIGY AG (CH) | 1980-10-01 | — | — | EP | claimed |
| EP-0000500-A2 | Cephalosprin derivatives, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1979-02-07 | — | — | EP | claimed |