Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394389 | 0.80 | MALT1 (0.46) | TP53LMNAPOLBNISCHMALT1 | |
| SCHEMBL11067202 | 0.80 | TP53 (0.49) | TP53LMNAPOLBNISCHMALT1 | |
| SCHEMBL8394386 | 0.80 | MALT1 (0.46) | TP53LMNAPOLBNISCHMALT1 | |
| SCHEMBL8394387 | 0.80 | MALT1 (0.46) | TP53LMNAPOLBNISCHMALT1 | |
| Hydrochloric Acid SCHEMBL21810865 | 0.79 | TP53 (0.45) | TP53LMNAPOLBNISCHMALT1 | |
| SCHEMBL433595 | 0.76 | GRIN2B (0.52) | GRIN2BSIGMAR1 | |
| SCHEMBL9501240 | 0.76 | TP53 (0.43) | TP53LMNAPOLBMALT1MAPT | |
| SCHEMBL28148475 | 0.75 | TP53 (0.57) | TP53LMNAPOLBP2RX7MALT1 | |
| SCHEMBL22543461 | 0.73 | TP53 (0.47) | TP53LMNAPOLBGRIN2BP2RX7 | |
| SCHEMBL5239331 | 0.73 | SIGMAR1 (0.49) | TP53LMNAPOLBSIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181550-B1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER IP GMBH (DE) | 2019-11-20 | — | — | EP | claimed |
| US-10093611-B2 | Benzocycloalkenes as antifungal agents | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2018-10-09 | — | — | US | claimed |
| EP-3181550-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | Bayer Intellectual Property GmbH (DE) | 2017-06-21 | — | — | EP | claimed |
| US-20160023987-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-01-28 | — | — | US | claimed |
| CN-103003246-B | As the benzo ring alkene of anti-mycotic agent | BAYER CROPSCIENCE AG (DE) | 2015-11-25 | — | — | CN | claimed |
| EP-2595961-A2 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | Bayer Intellectual Property GmbH (DE) | 2013-05-29 | — | — | EP | claimed |
| US-20130123322-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-16 | — | — | US | claimed |
| WO-2012010579-A2 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER CROPSCIENCE AG (DE) | 2012-01-26 | — | — | WO | claimed |
| EP-3181550-B1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER IP GMBH (DE) | 2019-11-20 | — | — | EP | disclosed |
| US-10093611-B2 | Benzocycloalkenes as antifungal agents | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2018-10-09 | — | — | US | disclosed |
| EP-3181550-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | Bayer Intellectual Property GmbH (DE) | 2017-06-21 | — | — | EP | disclosed |
| US-20160023987-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-01-28 | — | — | US | disclosed |
| CN-103003246-B | As the benzo ring alkene of anti-mycotic agent | BAYER CROPSCIENCE AG (DE) | 2015-11-25 | — | — | CN | disclosed |
| US-9173399-B2 | Benzocycloalkenes as antifungal agents | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| EP-2595961-A2 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | Bayer Intellectual Property GmbH (DE) | 2013-05-29 | — | — | EP | disclosed |
| US-20130123322-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-16 | — | — | US | disclosed |
| WO-2012010579-A2 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER CROPSCIENCE AG (DE) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160023987-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | CYP51A1, ERG28, CBR1 | TP53 4570/4885LMNA 2084/4885POLB 3888/4885 |
| US-10093611-B2 | Benzocycloalkenes as antifungal agents | CYP51A1, ERG28, CBR1 | TP53 4570/4885LMNA 2084/4885POLB 3888/4885 |
| US-20130123322-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | CYP51A1, ERG28, CBR1 | TP53 4570/4885LMNA 2084/4885POLB 3888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.