Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL4610063

CCCCCCCCCc1ccccc1OP(O)(=S)S.S

nearest known ligand 0.52

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRA P10827 1/20 0.52
THRB P10828 1/20 0.52
LIPG Q9Y5X9 1/20 0.46
ALOX5 P09917 1/20 0.46
PTGS2 P35354 1/20 0.46
PPARA Q07869 3/20 0.45
PPARG P37231 2/20 0.45
BID P55957 3/20 0.40
MCL1 Q07820 3/20 0.40
BCL2L1 Q07817 2/20 0.40
BAK1 Q16611 2/20 0.40
KAT8 Q9H7Z6 2/20 0.40
EP300 Q09472 1/20 0.40
KAT2A Q92830 1/20 0.40
KAT2B Q92831 1/20 0.40
KAT5 Q92993 1/20 0.40
SAE1 Q9UBE0 1/20 0.40
ENPP2 Q13822 1/20 0.38
LTB4R Q15722 1/20 0.38
LTB4R2 Q9NPC1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Sulfide SCHEMBL9821128 0.99 THRA (0.51) THRATHRBLIPGALOX5PTGS2
SCHEMBL3929117 0.99 THRA (0.53) THRATHRBLIPGALOX5PTGS2
SCHEMBL4980580 0.99 THRA (0.53) THRATHRBLIPGALOX5PTGS2
SCHEMBL1001010 0.99 THRA (0.53) THRATHRBLIPGALOX5PTGS2
Water SCHEMBL27918100 0.97 THRA (0.52) THRATHRBLIPGALOX5PTGS2
SCHEMBL27275672 0.97 THRA (0.52) THRATHRBLIPGALOX5PTGS2
SCHEMBL10625276 0.97 THRA (0.52) THRATHRBLIPGALOX5PTGS2
Water SCHEMBL27424481 0.96 THRA (0.51) THRATHRBLIPGALOX5PTGS2
SCHEMBL27734403 0.94 THRA (0.53) THRATHRBLIPGALOX5PTGS2
Hydrogen Sulfide SCHEMBL4609016 0.94 THRA (0.45) THRATHRBLIPGALOX5PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0208541-B1 LUBRICANT COMPOSITIONS NIPPON OIL CO. LTD. (JP) 1991-12-04 EP claimed
EP-0208541-A2 Lubricant compositions NIPPON OIL CO. LTD. (JP) 1987-01-14 EP claimed
EP-1979449-A1 GREASE COMPOSITION Shell Internationale Research Maatschappij B.V. (NL) 2008-10-15 EP disclosed
WO-2007085643-A1 GREASE COMPOSITION SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 2007-08-02 WO disclosed
EP-1046700-A2 Grease composition for constant velocity joint Showa Shell Sekiyu Kabushiki Kaisha (JP) 2000-10-25 EP disclosed
EP-0281060-A2 Lubricating oil compositions for traction drive IDEMITSU KOSAN COMPANY LIMITED (JP) 1988-09-07 EP disclosed