Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 9/20 | 0.40 |
| ▸ | CA2 | P00918 | 9/20 | 0.40 |
| ▸ | CA9 | Q16790 | 8/20 | 0.40 |
| ▸ | CA12 | O43570 | 6/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069769 | 0.82 | PTGES2 (0.42) | STAT3SCN9ACA1CA2CA9 | |
| SCHEMBL48885 | 0.77 | CA2 (0.52) | SCN9ACA1CA2CA9CA12 | |
| Acetic Acid SCHEMBL6695169 | 0.76 | SCN9A (0.50) | SCN9ACA1CA2CA9CA12 | |
| SCHEMBL2896796 | 0.76 | LRRK2 (0.51) | STAT3CA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL6399557 | 0.75 | CA2 (0.50) | SCN9ACA1CA2CA9CA12 | |
| Methane SCHEMBL27503773 | 0.75 | CA2 (0.50) | SCN9ACA1CA2CA9CA12 | |
| SCHEMBL4610078 | 0.74 | STAT3 (0.41) | STAT3CA1CA2CA9CA12 | |
| SCHEMBL21617314 | 0.74 | CA2 (0.50) | STAT3CA1CA2CA9CA12 | |
| SCHEMBL1337562 | 0.74 | PDCD1 (0.39) | CA2CYP2C9CDK8CDK5CLK4 | |
| SCHEMBL184009 | 0.74 | CA2 (0.46) | STAT3CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907357-A1 | ANILINE SULFONAMIDE DERIVATIVES AND THEIR USES | Amgen Inc. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007013929-A1 | ANILINE SULFONAMIDE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2007-02-01 | — | — | WO | disclosed |