Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 5/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.53 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11290298 | 0.78 | NR1H3 (0.44) | NR1H3NR1H2ESR1NR1I2KMT2A | |
| SCHEMBL6917666 | 0.77 | NR1H3 (0.69) | NR1H3NR1H2NR1I2ALDH1A1APOBEC3G | |
| SCHEMBL28982649 | 0.77 | NR1H2 (0.47) | NR1H3NR1H2ESR1NR1I2ALDH1A1 | |
| SCHEMBL3279350 | 0.71 | APOBEC3G (0.48) | NR1H3NR1H2ESR1NR1I2ALDH1A1 | |
| SCHEMBL29229990 | 0.70 | CA12 (0.60) | NR1H3NR1H2ESR1ALDH1A1KMT2A | |
| SCHEMBL9717953 | 0.70 | APOBEC3G (0.52) | ESR1NR1I2ALDH1A1KMT2AHSD11B1 | |
| SCHEMBL12084059 | 0.70 | APOBEC3G (0.52) | NR1H3ALDH1A1KMT2AHSD11B1APOBEC3G | |
| SCHEMBL812702 | 0.70 | CA12 (0.78) | NR1H3NR1H2NR1I2KMT2A | |
| SCHEMBL6562369 | 0.69 | KMT2A (0.54) | NR1H3NR1H2NR1I2KMT2AHSD11B1 | |
| SCHEMBL7601566 | 0.69 | HSD11B1 (0.50) | NR1H3ESR1NR1I2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907357-A1 | ANILINE SULFONAMIDE DERIVATIVES AND THEIR USES | Amgen Inc. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007013929-A1 | ANILINE SULFONAMIDE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2007-02-01 | — | — | WO | disclosed |