Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12025777 | 1.00 | CTSK (0.43) | CTSKCTSSITGB3ITGA2BF2R | |
| SCHEMBL4610242 | 1.00 | CTSK (0.43) | CTSKCTSSITGB3ITGA2BF2R | |
| SCHEMBL26448028 | 0.90 | CTSK (0.51) | CTSKCTSSITGB3ITGA2BNFKB1 | |
| SCHEMBL26087420 | 0.90 | CTSK (0.51) | CTSKCTSSITGB3ITGA2BNFKB1 | |
| SCHEMBL17373551 | 0.88 | CTSS (0.53) | CTSKCTSSITGB3ITGA2BF2R | |
| SCHEMBL6386727 | 0.88 | CTSS (0.53) | CTSKCTSSITGB3ITGA2BF2R | |
| SCHEMBL27444793 | 0.86 | CTSK (0.54) | CTSKCTSSITGB3ITGA2BNFKB1 | |
| SCHEMBL23836574 | 0.83 | CTSS (0.48) | CTSKCTSSITGB3ITGA2BF2R | |
| SCHEMBL12025751 | 0.83 | ITGB3 (0.45) | CTSKCTSSITGB3ITGA2BNFKB1 | |
| SCHEMBL12025778 | 0.83 | ITGB3 (0.45) | CTSKCTSSITGB3ITGA2BNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606283-B1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2008-10-08 | — | — | EP | disclosed |