Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22075884 | 0.87 | TSHR (0.35) | HPSEMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL2105626 | 0.73 | RIPK1 (0.34) | — | |
| SCHEMBL22075862 | 0.66 | SMN1; SMN2 (0.41) | HPSEMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL7705910 | 0.66 | CA2 (0.32) | TSHR | |
| SCHEMBL22075572 | 0.62 | TSHR (0.37) | HPSEMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL5816755 | 0.61 | PDE10A (0.50) | HPSENOS3NOS1NOS2TSHR | |
| SCHEMBL5326138 | 0.61 | NOS3 (0.49) | HPSENOS3NOS1NOS2MEN1 | |
| SCHEMBL5303902 | 0.59 | TLR8 (0.48) | HPSENOS3NOS1NOS2SIGMAR1 | |
| SCHEMBL5814723 | 0.59 | NOS3 (0.43) | HPSENOS3NOS1NOS2MEN1 | |
| SCHEMBL5305112 | 0.59 | RECQL (0.46) | HPSENOS3NOS1NOS2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981880-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |