Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.67 |
| ▸ | MMP9 | P14780 | 7/20 | 0.67 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.63 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.56 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
| ▸ | MMP7 | P09237 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 4/20 | 0.54 |
| ▸ | CTSS | P25774 | 4/20 | 0.54 |
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11704464 | 0.91 | MMP2 (0.71) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL3002038 | 0.91 | MMP2 (0.71) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL697592 | 0.84 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL4188026 | 0.84 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL697591 | 0.84 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL7960060 | 0.84 | MMP2 (0.65) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL9658885 | 0.84 | KMT2A (0.53) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL19450360 | 0.82 | MMP2 (0.67) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL7970164 | 0.82 | MMP2 (0.62) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL6019308 | 0.81 | CTSS (0.64) | MMP2MMP9ADAMTS4CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979332-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007083089-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-07-26 | — | — | WO | disclosed |