Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388358 | 0.79 | DHFR (0.71) | DHFRADORA1ADORA2AFGFR1 | |
| SCHEMBL30401146 | 0.79 | DHFR (0.71) | DHFRADORA1ADORA2AFGFR1 | |
| SCHEMBL27631899 | 0.78 | DHFR (0.69) | DHFRADORA1ADORA2A | |
| SCHEMBL1388331 | 0.76 | DHFR (0.67) | DHFRADORA1ADORA2A | |
| SCHEMBL30488016 | 0.76 | ADORA1 (0.70) | DHFRADORA1ADORA2AFGFR1 | |
| SCHEMBL1116404 | 0.76 | ADORA1 (0.70) | DHFRADORA1ADORA2AFGFR1SRC | |
| SCHEMBL29913330 | 0.76 | DHFR (1.00) | DHFRADORA1ADORA2AFGFR1SRC | |
| SCHEMBL1388562 | 0.76 | DHFR (1.00) | DHFRADORA1ADORA2AFGFR1SRC | |
| SCHEMBL1388335 | 0.76 | DHFR (0.67) | DHFRADORA1ADORA2AFGFR1 | |
| SCHEMBL1388276 | 0.76 | ADORA1 (0.70) | DHFRADORA1ADORA2AFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981856-A2 | PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085833-A2 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |