Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040126 | 0.97 | DNM1 (0.40) | DNM1KDM4EPMP22ATMSLC22A1 | |
| SCHEMBL203211 | 0.81 | TSHR (0.44) | KDM4EPMP22ATMTSHRNFKB1 | |
| SCHEMBL18905779 | 0.76 | NAAA (0.42) | ALDH1A1TP53 | |
| Bromide SCHEMBL18889108 | 0.75 | NAAA (0.41) | DNM1ALDH1A1TP53 | |
| SCHEMBL8020779 | 0.73 | SLC22A1 (0.62) | DNM1SLC22A1TSHRSLC22A2ALDH1A1 | |
| SCHEMBL8026840 | 0.73 | SLC22A1 (0.62) | DNM1SLC22A1TSHRSLC22A2ALDH1A1 | |
| SCHEMBL7051423 | 0.73 | SLC22A1 (0.62) | DNM1SLC22A1TSHRSLC22A2ALDH1A1 | |
| SCHEMBL11758406 | 0.72 | TSHR (0.50) | DNM1KDM4EPMP22ATMSLC22A1 | |
| SCHEMBL6577401 | 0.71 | DNM1 (0.65) | DNM1KDM4EPMP22ATMSLC22A1 | |
| SCHEMBL30554996 | 0.70 | SLC22A1 (0.50) | SLC22A1TSHRSLC22A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856033-B1 | IMPROVED METHOD FOR PRODUCING BI-FUNCTIONAL AMMONIUM NITRILES | CLARIANT PRODUKTE DEUTSCHLAND (DE) | 2008-10-22 | — | — | EP | disclosed |
| US-20080139838-A1 | Method for Producing Bi-Functional Ammonium Nitriles | REINHARDT GERD | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139838-A1 | Method for Producing Bi-Functional Ammonium Nitriles | NAAA, BCHE, DAO | DNM1 454/4885KDM4E 1970/4885PMP22 1737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.