Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3220050 | 1.00 | CCR6 (0.39) | CCR6PAX8ALDH1A1CA12CA1 | |
| SCHEMBL3220065 | 1.00 | CCR6 (0.39) | CCR6PAX8ALDH1A1CA12CA1 | |
| SCHEMBL3221814 | 0.80 | SYK (0.46) | ALDH1A1CA12CA1LMNAMEN1 | |
| SCHEMBL3221836 | 0.80 | SYK (0.46) | ALDH1A1CA12CA1LMNAMEN1 | |
| SCHEMBL4611303 | 0.78 | CA1 (0.39) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL19541343 | 0.75 | ALDH1A1 (0.49) | ALDH1A1SLC15A1LMNAMEN1KMT2A | |
| SCHEMBL7761190 | 0.75 | ABCB1 (0.48) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL13494184 | 0.74 | ALDH1A1 (0.44) | CCR6PAX8ALDH1A1PTGDR2KMT2A | |
| SCHEMBL27464981 | 0.72 | CCR6 (0.40) | CCR6PAX8ALDH1A1CA12CA1 | |
| SCHEMBL22402324 | 0.72 | ALDH1A1 (0.51) | ALDH1A1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |