Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3220065 | 0.78 | CCR6 (0.39) | CA1CA2CA12CA9SLC15A1 | |
| SCHEMBL3220050 | 0.78 | CCR6 (0.39) | CA1CA2CA12CA9SLC15A1 | |
| SCHEMBL4612245 | 0.78 | CCR6 (0.39) | CA1CA2CA12CA9SLC15A1 | |
| SCHEMBL28441928 | 0.73 | MEN1 (0.39) | CA1CA2CA12CA9SLC15A1 | |
| SCHEMBL19541343 | 0.73 | ALDH1A1 (0.49) | SLC15A1MEN1KMT2AALDH1A1SLC1A3 | |
| SCHEMBL28619523 | 0.72 | CA2 (0.48) | CA1CA2CA12CA9MEN1 | |
| SCHEMBL7761190 | 0.72 | ABCB1 (0.48) | CA1CA2CA12CA9KMT2A | |
| SCHEMBL28434500 | 0.70 | CA2 (0.51) | CA1CA2CA12CA9MEN1 | |
| SCHEMBL13684205 | 0.70 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL22402324 | 0.70 | ALDH1A1 (0.51) | CA1CA2CA12CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |