Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 19/20 | 0.72 |
| ▸ | CTSB | P07858 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4612925 | 1.00 | CTSK (0.72) | CTSKCTSBCTSLCTSS | |
| SCHEMBL6137146 | 1.00 | CTSK (0.72) | CTSKCTSBCTSLCTSS | |
| SCHEMBL4614484 | 0.89 | CTSK (0.75) | CTSKCTSBCTSLCTSS | |
| SCHEMBL4615308 | 0.89 | CTSK (0.75) | CTSKCTSBCTSLCTSS | |
| SCHEMBL4614481 | 0.89 | CTSK (0.75) | CTSKCTSBCTSLCTSS | |
| SCHEMBL4613133 | 0.88 | CTSK (0.76) | CTSKCTSBCTSLCTSS | |
| SCHEMBL4613136 | 0.88 | CTSK (0.76) | CTSKCTSBCTSLCTSS | |
| SCHEMBL4613139 | 0.88 | CTSK (0.76) | CTSKCTSBCTSLCTSS | |
| SCHEMBL4614319 | 0.87 | CTSK (0.78) | CTSKCTSBCTSLCTSS | |
| SCHEMBL4614324 | 0.87 | CTSK (0.78) | CTSKCTSBCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371747-B2 | Cyanoalkylamino derivatives as protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2008-05-13 | — | — | US | disclosed |
| EP-1446115-B1 | CYANOALKYLAMINO DERIVATIVES AS PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-02-27 | — | — | EP | disclosed |
| US-20050014941-A1 | Cyanoalkylamino derivatives as protease inhibitors | MERCK FROSST CANADA LTD. (CA) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014941-A1 | Cyanoalkylamino derivatives as protease inhibitors | CTSB, CTSK, CTSS | CTSK 2/4885CTSB 1/4885CTSL 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.