Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | CASR | P41180 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000918 | 0.83 | PNMT (0.60) | SLC6A4SLC6A2PNMTIDO1TDO2 | |
| SCHEMBL6006319 | 0.83 | SLC6A4 (0.64) | SLC6A4SLC6A2HRH1HTR2ATAAR1 | |
| SCHEMBL365056 | 0.77 | SLC6A4 (0.42) | SLC6A4SLC6A2PNMTIDO1TDO2 | |
| SCHEMBL7289657 | 0.74 | PNMT (0.50) | SLC6A4SLC6A2PNMTIDO1TDO2 | |
| SCHEMBL9210534 | 0.74 | PNMT (0.60) | SLC6A4SLC6A2PNMTIDO1TDO2 | |
| SCHEMBL6867802 | 0.72 | CASR (0.65) | SLC6A4SLC6A2SLC6A3ADRA2CHTR2C | |
| SCHEMBL14387381 | 0.71 | SLC6A4 (0.48) | SLC6A4SLC6A2PNMTIDO1TDO2 | |
| SCHEMBL14387383 | 0.71 | SLC6A2 (0.48) | SLC6A4SLC6A2IDO1TDO2SLC6A3 | |
| SCHEMBL27956998 | 0.70 | CASR (0.44) | SLC6A4SLC6A2PNMTSLC6A3ADRA2C | |
| SCHEMBL6868488 | 0.70 | CASR (0.63) | SLC6A4SLC6A2SLC6A3ADRA2CHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928817-A1 | PROCESS FOR THE PREPARATION OF CINACALCET BASE | Teva Pharmaceutical Industries Ltd (IL) | 2008-06-11 | — | — | EP | disclosed |
| EP-1915335-A2 | PROCESS FOR THE PREPARATION OF CINACALCET BASE | Teva Pharmaceutical Industries Ltd (IL) | 2008-04-30 | — | — | EP | disclosed |
| EP-1881954-A2 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-01-30 | — | — | EP | disclosed |
| WO-2007127445-A2 | PROCESS FOR THE PREPARATION OF CINACALCET BASE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-11-08 | — | — | WO | disclosed |
| WO-2007127449-A1 | PROCESS FOR THE PREPARATION OF CINACALCET BASE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-11-08 | — | — | WO | disclosed |
| WO-2006125026-A2 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2006-11-23 | — | — | WO | disclosed |