Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294209 | 0.85 | HRH3 (0.48) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL6000918 | 0.83 | PNMT (0.60) | PNMTSLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL7295270 | 0.82 | SLC6A2 (0.48) | SLC6A2SLC6A4IDO1TDO2CHRM2 | |
| SCHEMBL9812324 | 0.81 | SLC6A2 (0.63) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL7295479 | 0.80 | SLC6A2 (0.49) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL17842112 | 0.79 | PNMT (0.49) | PNMTSLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL29096044 | 0.79 | SLC6A3 (0.64) | PNMTSLC6A2SLC6A4IDO1TDO2 | |
| SCHEMBL7276627 | 0.78 | SLC6A2 (0.47) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL7277039 | 0.76 | NPY1R (0.47) | SLC6A2SLC6A4IDO1TDO2CHRM2 | |
| SCHEMBL7276674 | 0.75 | SLC6A2 (0.51) | SLC6A2SLC6A4CHRM2SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262448-B1 | IMIDAZOLYLGUANIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1991-12-18 | — | — | EP | disclosed |
| US-4912119-A | Cardiovascular disorders | HEUMANN PHARMA GMBH & CO. (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0262448-A1 | Imidazolylguanidine derivatives, process for their preparation and medicines containing them | HEUMANN PHARMA GMBH & CO (DE) | 1988-04-06 | — | — | EP | disclosed |