Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.40 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251204 | 0.92 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL954016 | 0.92 | ALDH1A1 (0.44) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL24093 | 0.92 | ALDH1A1 (0.44) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL9422101 | 0.92 | ALDH1A1 (0.44) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Water SCHEMBL6447465 | 0.90 | MAPT (0.42) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Butadiene SCHEMBL9420166 | 0.90 | MAPT (0.42) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL4101735 | 0.87 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL5337661 | 0.85 | ALDH1A1 (0.42) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL1579931 | 0.84 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL5141317 | 0.81 | HDAC3 (0.47) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446518-B9 | POLYOLEFIN-BASED SYNTHETIC FIBERS AND PRODUCTION METHOD THEREOF | AQUAFIL S P A (IT) | 2008-03-05 | — | — | EP | claimed |
| EP-1446518-B1 | POLYOLEFIN-BASED SYNTHETIC FIBERS AND PRODUCTION METHOD THEREOF | AQUAFIL S P A (IT) | 2007-10-10 | — | — | EP | claimed |