Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707431 | 0.83 | MAOA (0.31) | MAOAMAOB | |
| SCHEMBL9423400 | 0.75 | — | — | |
| SCHEMBL7684525 | 0.72 | — | — | |
| SCHEMBL6407297 | 0.71 | CTH (0.31) | MAOAMAOB | |
| SCHEMBL9723736 | 0.71 | BACE1 (0.39) | MAOAMAOB | |
| SCHEMBL2199751 | 0.69 | MAOA (0.30) | MAOAMAOB | |
| SCHEMBL10700502 | 0.69 | MAOA (0.30) | MAOAMAOB | |
| SCHEMBL12532851 | 0.69 | TSHR (0.31) | — | |
| SCHEMBL2193087 | 0.69 | NSD2 (0.32) | MAOAMAOB | |
| SCHEMBL497511 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2705036-A1 | TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN INC. (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2595988-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012154678-A1 | TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-11-15 | — | — | WO | disclosed |
| WO-2012012642-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-01-26 | — | — | WO | disclosed |
| US-4369316-A | 3,1 Benzoxazine 2,4-dione | ICI AMERICAS INC. (US) | 1983-01-18 | — | — | US | disclosed |
| US-4314078-A | Process for preparing 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitro-N-alkanesulphonyl benzamides from a benzoic acid derivative and intermediates | ICI AMERICAS INC. (US) | 1982-02-02 | — | — | US | disclosed |