Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.86 |
| ▸ | HPGD | P15428 | 6/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.86 |
| ▸ | CA12 | O43570 | 1/20 | 0.86 |
| ▸ | CA1 | P00915 | 1/20 | 0.86 |
| ▸ | CA2 | P00918 | 1/20 | 0.86 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.86 |
| ▸ | CA4 | P22748 | 1/20 | 0.86 |
| ▸ | CA6 | P23280 | 1/20 | 0.86 |
| ▸ | CA7 | P43166 | 1/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.86 |
| ▸ | CA9 | Q16790 | 1/20 | 0.86 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.86 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.86 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.67 |
| ▸ | HNF4A | P41235 | 3/20 | 0.67 |
| ▸ | DHFR | P00374 | 1/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.67 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL29360246 | 0.93 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL29362663 | 0.93 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL29606432 | 0.93 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL1967 | 0.93 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL1509155 | 0.93 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL17156443 | 0.93 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL8433746 | 0.93 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL546853 | 0.90 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL9691144 | 0.90 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL224819 | 0.90 | ALDH1A1 (0.95) | ALDH1A1HPGDKDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106317810-B | Liquid crystal polymer composite film | 财团法人工业技术研究院 | 2018-09-21 | — | — | CN | claimed |
| CN-106317810-B | Liquid crystal polymer composite film | 财团法人工业技术研究院 | 2018-09-21 | — | — | CN | disclosed |
| EP-2325651-B1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INST (US) | 2014-10-08 | — | — | EP | disclosed |
| US-20140134753-A1 | METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-05-15 | — | — | US | disclosed |
| US-8653119-B2 | Methods for treating transthyretin amyloid diseases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-02-18 | — | — | US | disclosed |
| US-8168663-B2 | Pharmaceutically acceptable salt of 6-carboxy-2-(3,5 dichlorophenyl)-benzoxazole, and a pharmaceutical composition comprising the salt thereof | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-05-01 | — | — | US | disclosed |
| US-20120065237-A1 | METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-03-15 | — | — | US | disclosed |
| EP-1988397-B1 | COMPOSITIONS AND USES FOR STABILISING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | SCRIPPS RESEARCH INST (US) | 2011-09-14 | — | — | EP | disclosed |
| EP-2325651-A2 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-05-25 | — | — | EP | disclosed |
| US-20100120919-A1 | METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-05-13 | — | — | US | disclosed |
| US-20070078186-A1 | Methods for treating transthyretin amyloid diseases | THE SCRIPPS RESEARCH INSTITUTE | 2007-04-05 | — | — | US | disclosed |
| EP-0976399-B1 | Process for the production of a propolis extract comprising an anion-exchange step | HAYASHIBARA BIOCHEM LAB (JP) | 2006-04-12 | — | — | EP | disclosed |
| US-20060057644-A1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | SCRIPPS RESEARCH INSTITUTE, THE | 2006-03-16 | — | — | US | disclosed |
| EP-1587821-A2 | COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | The Scripps Research Institute (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20040152140-A1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | THE SCRIPPS RESEARCH INSTITUTE | 2004-08-05 | — | — | US | disclosed |
| WO-2004056315-A2 | COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-07-08 | — | — | WO | disclosed |
| US-6153228-A | A DEODORIZED PROPOLIS EXTRACT WHEREIN THE AMOUNT OF AT LEAST ONE ODORIZING INGREDIENT IS REDUCED; TESTING USING GAS CHROMATOGRAPHY; COSMETICS; DRUGS; FOODS | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2000-11-28 | — | — | US | disclosed |
| US-6153227-A | REDUCING THE ODOR BY SOAKING PROPOLIS IN A HYDROPHILIC SOLVENT, E.G., METHANOL, TO EFFECT EXTRACTION FOLLOWED BY TREATING THE LIQUID LAYER WITH AN ANION EXCHANGE RESIN; WITHOUT ATTENUATING THE INHERENT BIOLOGICAL ACTIVITIES | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2000-11-28 | — | — | US | disclosed |
| EP-0976399-A1 | Propolis extract | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2000-02-02 | — | — | EP | disclosed |
| CN-1067913-A | Polymer composites of thermoplasticity and liquid crystalline polymers and preparation method thereof | BP AMERICA (US) | 1993-01-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078186-A1 | Methods for treating transthyretin amyloid diseases | TTR, TTPA, PRNP | ALDH1A1 2744/4885HPGD 2551/4885KDM4E 4518/4885 |
| US-20120065237-A1 | METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES | TTR, TTPA, PRNP | ALDH1A1 2744/4885HPGD 2551/4885KDM4E 4518/4885 |
| US-20100120919-A1 | METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES | TTR, TTPA, PRNP | ALDH1A1 2744/4885HPGD 2551/4885KDM4E 4518/4885 |
| US-20060057644-A1 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding | TTR, TTPA, PRNP | ALDH1A1 3491/4885HPGD 3422/4885KDM4E 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.