Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paraben. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.64 |
| ▸ | CA12 | O43570 | 2/20 | 0.64 |
| ▸ | CA1 | P00915 | 2/20 | 0.64 |
| ▸ | CA7 | P43166 | 2/20 | 0.64 |
| ▸ | CA9 | Q16790 | 2/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.64 |
| ▸ | CA3 | P07451 | 1/20 | 0.64 |
| ▸ | TYR | P14679 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | CA4 | P22748 | 1/20 | 0.64 |
| ▸ | CA6 | P23280 | 1/20 | 0.64 |
| ▸ | CA5A | P35218 | 1/20 | 0.64 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.64 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL10938231 | 0.92 | TSHR (0.57) | CA2CA12CA1CA7CA9 | |
| Terephthalic Acid SCHEMBL855281 | 0.92 | TSHR (0.57) | CA2CA12CA1CA7CA9 | |
| Terephthalic Acid SCHEMBL28791012 | 0.92 | TSHR (0.57) | CA2CA12CA1CA7CA9 | |
| Terephthalic Acid SCHEMBL29132843 | 0.88 | TSHR (0.52) | CA2CA12CA1CA7CA9 | |
| Terephthalic Acid SCHEMBL11809850 | 0.88 | TSHR (0.52) | CA2CA12CA1CA7CA9 | |
| Terephthalic Acid SCHEMBL27843678 | 0.88 | TSHR (0.52) | CA2CA12CA1CA7CA9 | |
| Paraben SCHEMBL27174174 | 0.87 | CA2 (0.76) | CA2CA12CA1CA7CA9 | |
| Paraben SCHEMBL11470350 | 0.86 | CA2 (0.67) | CA2CA12CA1CA7CA9 | |
| 4-Methylbenzoic Acid SCHEMBL5081494 | 0.84 | ALDH1A1 (0.68) | CA2CA12CA1CA9SRD5A2 | |
| Terephthalic Acid SCHEMBL28992746 | 0.84 | USP5 (0.50) | CA2CA12CA1CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112770755-A | Compositions, syntheses, preparations and uses of analogs derived from position 7 and 9 of platform drug FL118 for treating human diseases | 坎格特生物技术制药有限责任公司 | 2021-05-07 | — | — | CN | claimed |
| CN-114621628-B | Sweetener and preparation method thereof | 福建鑫叶投资管理集团有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-112770755-A | Compositions, syntheses, preparations and uses of analogs derived from position 7 and 9 of platform drug FL118 for treating human diseases | 坎格特生物技术制药有限责任公司 | 2021-05-07 | — | — | CN | disclosed |
| US-10959985-B1 | Pharmaceutical compositions including carvedilol and methods of using the same | ECI Pharmaceuticals, LLC (US) | 2021-03-30 | — | — | US | disclosed |
| US-10772869-B1 | Pharmaceutical compositions including carvedilol and methods of using the same | ECI Pharmaceuticals, LLC (US) | 2020-09-15 | — | — | US | disclosed |
| US-9844538-B2 | Hyoscyamine dosage form | SOVEREIGN PHARMACEUTICALS, LLC (US) | 2017-12-19 | — | — | US | disclosed |
| US-9656103-B2 | Light protecting-effective cosmetic or dermatological preparations | BASF SE (DE) | 2017-05-23 | — | — | US | disclosed |
| US-9592197-B2 | Dosage form containing diphenhydramine and another drug | SOVEREIGN PHARMACEUTICALS, LLC (US) | 2017-03-14 | — | — | US | disclosed |
| US-9492541-B2 | Phenylepherine containing dosage form | SOVEREIGN PHARMACEUTICALS, LLC (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160213656-A1 | HYOSCYAMINE DOSAGE FORM | SOVEREIGN PHARMACEUTICALS, LLC | 2016-07-28 | — | — | US | disclosed |
| WO-2004000242-A1 | TOPICAL COSMETIC COMPOSITIONS | COSMECEUTIC SOLUTIONS PTY LTD (AU) | 2003-12-31 | — | — | WO | disclosed |
| US-6342209-B1 | NAIL ENAMEL COMPOSITION CONTAINING AT LEAST ONE FILM FORMING POLYMER, AT LEAST ONE SOLVENT, PLASTICIZER FOR FILM FORMING POLYMER WHICH IS LOWER ALKYL ESTER OF MALIC ACID | REVLON CONSUMER PRODUCTS CORPORATION | 2002-01-29 | — | — | US | disclosed |
| WO-2002000176-A1 | COSMETIC COMPOSITIONS CONTAINING KERATINIZATION MODULATORS AND METHODS FOR IMPROVING KERATINOUS SURFACES | REVLON CONSUMER PRODUCTS CORPORATION (US) | 2002-01-03 | — | — | WO | disclosed |
| WO-2001082866-A2 | COSMETIC COMPOSITIONS CONTAINING FILM FORMING POLYMERS PLASTICIZED WITH ESTERS OF MALIC ACID | REVLON CONSUMER PRODUCTS CORPORATION (US) | 2001-11-08 | — | — | WO | disclosed |
| US-6299890-B1 | COSMETICS, STABILITY | REVLON CONSUMER PRODUCTS CORPORATION | 2001-10-09 | — | — | US | disclosed |
| EP-0035518-B1 | COHESIVE NONSTICKY ELECTRICALLY CONDUCTIVE GEL COMPOSITION | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1986-01-22 | — | — | EP | disclosed |
| US-4406827-A | CROSSLINKED GUM, IONIXED SALT, BIOMEDICAL ELECTRODE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1983-09-27 | — | — | US | disclosed |
| EP-0035518-A4 | COHESIVE NONSTICKY ELECTRICALLY CONDUCTIVE GEL COMPOSITION. | MINNESOTA MINING & MFG (US) | 1982-02-05 | — | — | EP | disclosed |
| EP-0035518-A1 | COHESIVE NONSTICKY ELECTRICALLY CONDUCTIVE GEL COMPOSITION. | MINNESOTA MINING & MFG (US) | 1981-09-16 | — | — | EP | disclosed |
| WO-1981000785-A1 | COHESIVE NONSTICKY ELECTRICALLY CONDUCTIVE GEL COMPOSITION | MINNESOTA MINING & MFG (US) | 1981-03-19 | — | — | WO | disclosed |