Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.71 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.71 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27712948 | 0.91 | PRMT1 (0.64) | ALDH1A1PRMT1SFRP1AKR1C3HDAC2 | |
| SCHEMBL4618598 | 0.90 | SFRP1 (0.60) | ALDH1A1PRMT1SFRP1AKR1C3HDAC2 | |
| SCHEMBL4617723 | 0.90 | AKR1C3 (0.69) | ALDH1A1PRMT1SFRP1AKR1C3HDAC2 | |
| SCHEMBL4618968 | 0.90 | TAAR1 (0.68) | ALDH1A1PRMT1SFRP1AKR1C3HDAC2 | |
| SCHEMBL4617870 | 0.90 | ALDH1A1 (0.71) | ALDH1A1PRMT1SFRP1AKR1C3HDAC2 | |
| SCHEMBL4618106 | 0.90 | TDP1 (0.76) | ALDH1A1PRMT1SFRP1AKR1C3HDAC2 | |
| SCHEMBL4616446 | 0.89 | SFRP1 (0.58) | ALDH1A1PRMT1SFRP1AKR1C3HDAC2 | |
| SCHEMBL4672142 | 0.89 | AKR1C3 (0.70) | ALDH1A1PRMT1SFRP1AKR1C3HDAC2 | |
| SCHEMBL4618403 | 0.89 | CA1 (0.77) | ALDH1A1PRMT1SFRP1AKR1C3TDP1 | |
| SCHEMBL4618861 | 0.87 | AKR1C3 (0.71) | ALDH1A1PRMT1SFRP1AKR1C3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101208299-A | Diarylsulfone sulfonamides and use therof | WYETH CORP (US) | 2008-06-25 | — | — | CN | claimed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |
| CN-101208299-A | Diarylsulfone sulfonamides and use therof | WYETH CORP (US) | 2008-06-25 | — | — | CN | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | ALDH1A1 1865/4885PRMT1 867/4885SFRP1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.