Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL28337257 | 0.96 | SLC7A5 (0.35) | SLC7A5PTGS1SLC7A11 | |
| Leucine SCHEMBL196371 | 0.92 | MEN1 (0.34) | SLC7A5 | |
| Leucine SCHEMBL27660747 | 0.90 | SLC7A5 (0.46) | SLC7A5SLC1A3SLC1A2REN | |
| Leucine SCHEMBL6463330 | 0.90 | SLC7A5 (0.46) | SLC7A5SLC1A3SLC1A2REN | |
| Threonine SCHEMBL23270196 | 0.90 | PTGS1 (0.41) | PTGS1SLC7A11 | |
| Leucine SCHEMBL23270193 | 0.89 | SLC7A5 (0.47) | SLC7A5PTGS1SLC7A11SLC1A3SLC1A2 | |
| Leucine SCHEMBL28521469 | 0.89 | SLC7A5 (0.47) | SLC7A5PTGS1SLC7A11SLC1A3SLC1A2 | |
| D-Glutamate SCHEMBL28920113 | 0.89 | SLC1A3 (0.37) | SLC7A5SLC1A3SLC1A2REN | |
| Leucine SCHEMBL27509633 | 0.89 | SLC7A5 (0.37) | SLC7A5SLC1A3SLC1A2REN | |
| Leucine SCHEMBL1675456 | 0.88 | SLC7A5 (0.49) | SLC7A5SLC1A3SLC1A2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896081-A1 | HUMAN GRANULOCYTE-COLONY STIMULATING FACTOR ISOFORMS | CJ Corp. (KR) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006135176-A1 | HUMAN GRANULOCYTE-COLONY STIMULATING FACTOR ISOFORMS | CJ CORPORATION (KR) | 2006-12-21 | — | — | WO | disclosed |