Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL4616828 | 0.92 | SLC7A5 (0.38) | SLC7A5 | |
| Glutamine SCHEMBL8162435 | 0.88 | KMT2A (0.33) | MEN1KMT2A | |
| Glutamine SCHEMBL7167981 | 0.88 | KMT2A (0.33) | MEN1KMT2A | |
| Leucine SCHEMBL28337257 | 0.88 | SLC7A5 (0.35) | SLC7A5 | |
| Methionine SCHEMBL8465848 | 0.88 | MEN1 (0.38) | MEN1KMT2AFNTAFNTBPGGT1B | |
| Racemethionine SCHEMBL27660908 | 0.87 | MEN1 (0.41) | MEN1KMT2AFNTAFNTBPGGT1B | |
| D-Glutamate SCHEMBL28920113 | 0.85 | SLC1A3 (0.37) | SLC7A5 | |
| Racemethionine SCHEMBL23924542 | 0.84 | MEN1 (0.43) | MEN1KMT2A | |
| Methionine SCHEMBL3091904 | 0.84 | MEN1 (0.43) | MEN1KMT2A | |
| Methionine SCHEMBL4402781 | 0.84 | MEN1 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088899-B2 | Human granulocyte-colony stimulating factor isoforms | CJ CHEILJEDANG CORPORATION (KR) | 2012-01-03 | — | — | US | disclosed |
| US-20100143288-A1 | HUMAN GRANULOCYTE-COLONY STIMULATING FACTOR ISOFORMS | CJ CHEILJEDANG CORPORATION (KR) | 2010-06-10 | — | — | US | disclosed |