Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL4616828 | 0.96 | SLC7A5 (0.38) | SLC7A5PTGS1SLC7A11 | |
| Threonine SCHEMBL28072332 | 0.90 | — | — | |
| Leucine SCHEMBL15110225 | 0.89 | SLC7A5 (0.44) | SLC7A5 | |
| Leucine SCHEMBL196371 | 0.88 | MEN1 (0.34) | SLC7A5 | |
| Histidine SCHEMBL28633479 | 0.88 | — | — | |
| Threonine SCHEMBL6520771 | 0.88 | — | — | |
| Threonine SCHEMBL6520767 | 0.88 | — | — | |
| Threonine SCHEMBL23270196 | 0.87 | PTGS1 (0.41) | PTGS1SLC7A11 | |
| Leucine SCHEMBL6463330 | 0.87 | SLC7A5 (0.46) | SLC7A5 | |
| Leucine SCHEMBL27660747 | 0.87 | SLC7A5 (0.46) | SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110627880-B | Isolated polypeptides and uses thereof | 武汉合生科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-110627880-A | Isolated polypeptides and uses thereof | 武汉臻智生物科技有限公司 | 2019-12-31 | — | — | CN | claimed |
| CN-110627880-B | Isolated polypeptides and uses thereof | 武汉合生科技有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-110627880-A | Isolated polypeptides and uses thereof | 武汉臻智生物科技有限公司 | 2019-12-31 | — | — | CN | disclosed |