Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 5/20 | 0.43 |
| ▸ | CES2 | O00748 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695035 | 0.76 | CES1 (0.46) | SMN1; SMN2MAPTLMNAATMCES1 | |
| SCHEMBL7215594 | 0.75 | CES2 (0.59) | SMN1; SMN2NPSR1MAPTLMNAXBP1 | |
| SCHEMBL28283115 | 0.74 | TDP1 (0.56) | SMN1; SMN2NPSR1MAPTLMNAXBP1 | |
| SCHEMBL15956056 | 0.74 | TSHR (0.52) | SMN1; SMN2NPSR1MAPTLMNAXBP1 | |
| SCHEMBL163939 | 0.74 | TDP1 (0.56) | SMN1; SMN2NPSR1MAPTLMNAXBP1 | |
| SCHEMBL26080871 | 0.73 | PGR (0.42) | SMN1; SMN2NPSR1MAPTLMNAXBP1 | |
| SCHEMBL28158669 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1MAPTLMNAXBP1 | |
| SCHEMBL7370238 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1MAPTLMNAXBP1 | |
| SCHEMBL3244408 | 0.72 | NPSR1 (0.43) | SMN1; SMN2NPSR1MAPTLMNAXBP1 | |
| Benzil SCHEMBL11293167 | 0.72 | CES2 (0.70) | SMN1; SMN2NPSR1MAPTLMNAXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893585-A1 | PROCESS FOR THE PREPARATION OF N-[4-(4-FLUOROPHENYL)-5-FORMYL-6-ISOPROPYL-PYRIMIDIN-2-YL]-N-METHYLMETHANESULFONAMIDE | Fermion Oy (FI) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006128954-A1 | PROCESS FOR THE PREPARATION OF N-[4-(4-FLUOROPHENYL)-5-FORMYL-6-ISOPROPYL-PYRIMIDIN-2-YL]-N-METHYLMETHANESULFONAMIDE | FERMION OY (FI) | 2006-12-07 | — | — | WO | disclosed |