Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.36 |
| ▸ | HTR7 | P34969 | 7/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 11/20 | 0.35 |
| ▸ | WNT3 | P56703 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619043 | 0.85 | HTR1A (0.42) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4617920 | 0.83 | HTR1A (0.45) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4617601 | 0.81 | HTR1A (0.44) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4616210 | 0.81 | KDM4E (0.46) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4617737 | 0.80 | ALDH1A1 (0.46) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4618933 | 0.80 | HTR1A (0.41) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4617906 | 0.79 | SFRP1 (0.56) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL6103313 | 0.79 | HTR1A (0.42) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4615580 | 0.78 | IKBKB (0.42) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL6102396 | 0.77 | SFRP1 (0.51) | SFRP1WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |