Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2058594 | 0.91 | ITGB1 (0.48) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL8048237 | 0.91 | ITGB1 (0.48) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL13043085 | 0.88 | RAB9A (0.39) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL17822346 | 0.86 | ALDH1A1 (0.55) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL17822347 | 0.86 | ALDH1A1 (0.55) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL31524158 | 0.83 | NPC1 (0.49) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL2951695 | 0.82 | ALDH1A1 (0.59) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL5009929 | 0.81 | ALDH1A1 (0.62) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL5013682 | 0.80 | ALDH1A1 (0.55) | SMN1; SMN2NPC1MAPTRAB9AHTT | |
| SCHEMBL3729750 | 0.78 | ACACB (0.50) | CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940827-A1 | CARBAMATE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007041324-A1 | CARBAMATE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 2007-04-12 | — | — | WO | claimed |
| EP-1940827-A1 | CARBAMATE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007041324-A1 | CARBAMATE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 2007-04-12 | — | — | WO | disclosed |