Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4616943 | 0.93 | SFRP1 (0.65) | SFRP1SIGMAR1 | |
| SCHEMBL4616164 | 0.89 | SFRP1 (0.54) | SFRP1SIGMAR1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4618147 | 0.88 | SFRP1 (0.71) | SFRP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4618631 | 0.86 | SFRP1 (0.76) | SFRP1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4617938 | 0.86 | SIGMAR1 (0.57) | SFRP1SIGMAR1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4618150 | 0.83 | SFRP1 (0.77) | SFRP1SIGMAR1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4617158 | 0.82 | SFRP1 (0.71) | SFRP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL4618586 | 0.82 | SFRP1 (0.52) | SFRP1SIGMAR1KMT2AALDH1A1 | |
| SCHEMBL3712996 | 0.81 | SIGMAR1 (0.73) | SIGMAR1KMT2ASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL4616099 | 0.81 | SFRP1 (1.00) | SFRP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101208299-A | Diarylsulfone sulfonamides and use therof | WYETH CORP (US) | 2008-06-25 | — | — | CN | claimed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |
| CN-101208299-A | Diarylsulfone sulfonamides and use therof | WYETH CORP (US) | 2008-06-25 | — | — | CN | disclosed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | SFRP1 1/4885SIGMAR1 2411/4885KMT2A 3832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.