Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyruvate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyruvate SCHEMBL15322484 | 0.88 | LMNA (0.43) | ALDH1A1LMNAAKR1B1OR51E2 | |
| Pyruvate SCHEMBL2052994 | 0.88 | LMNA (0.53) | ALDH1A1LMNAOR51E2FFAR3LCK | |
| Pyruvate SCHEMBL30531673 | 0.88 | LMNA (0.53) | ALDH1A1LMNAOR51E2FFAR3LCK | |
| Glycerin SCHEMBL22720623 | 0.83 | LMNA (0.47) | ALDH1A1LMNAAKR1B1OR51E2FFAR3 | |
| Glycerin SCHEMBL1685695 | 0.83 | LMNA (0.60) | ALDH1A1LMNAAKR1B1OR51E2FFAR3 | |
| Glycerin SCHEMBL33458 | 0.83 | LMNA (0.60) | ALDH1A1LMNAAKR1B1OR51E2FFAR3 | |
| Glycerin SCHEMBL1685690 | 0.83 | LMNA (0.60) | ALDH1A1LMNAAKR1B1OR51E2FFAR3 | |
| Glycerin SCHEMBL203757 | 0.83 | LMNA (0.60) | ALDH1A1LMNAAKR1B1OR51E2FFAR3 | |
| Glycerin SCHEMBL15061 | 0.83 | LMNA (0.60) | ALDH1A1LMNAAKR1B1OR51E2FFAR3 | |
| Glycerin SCHEMBL1685689 | 0.83 | LMNA (0.60) | ALDH1A1LMNAAKR1B1OR51E2FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891203-A1 | TRANSFORMED SACCHAROMYCES YEAST STRAINS HAVING REDUCED ETHANOL PRODUCTION BY FERMENTATION | INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006134277-A1 | TRANSFORMED SACCHAROMYCES YEAST STRAINS HAVING REDUCED ETHANOL PRODUCTION BY FERMENTATION | INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR) | 2006-12-21 | — | — | WO | disclosed |