Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.52 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | SFRP1 | Q8N474 | 3/20 | 0.44 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617968 | 0.86 | LMNA (0.53) | LMNASLC12A2SLC12A5GLASFRP1 | |
| SCHEMBL4616119 | 0.82 | LMNA (0.57) | LMNASLC12A2SLC12A5GLASFRP1 | |
| SCHEMBL4618473 | 0.81 | LMNA (0.49) | LMNASLC12A2SLC12A5GLASFRP1 | |
| SCHEMBL13189167 | 0.80 | GBA1 (0.56) | LMNAALDH1A1KMT2AGBA1GAA | |
| SCHEMBL4617963 | 0.79 | LMNA (0.47) | LMNASLC12A2SLC12A5GLASFRP1 | |
| SCHEMBL4618655 | 0.76 | LMNA (0.56) | LMNASLC12A2SLC12A5GLASFRP1 | |
| SCHEMBL4616206 | 0.76 | SFRP1 (0.73) | LMNASLC12A2SLC12A5GLASFRP1 | |
| SCHEMBL4618233 | 0.75 | LMNA (0.48) | LMNASLC12A2SLC12A5GLASFRP1 | |
| SCHEMBL4617973 | 0.74 | LMNA (0.53) | LMNASLC12A2SLC12A5GLASFRP1 | |
| SCHEMBL4636847 | 0.73 | LMNA (0.47) | LMNASLC12A2SLC12A5GLASFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |