Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.46 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617971 | 0.89 | LMNA (0.45) | LMNAALDH1A1POLBSLC12A2SLC12A5 | |
| SCHEMBL4618233 | 0.83 | LMNA (0.48) | LMNAALDH1A1POLBSLC12A2SLC12A5 | |
| SCHEMBL14676619 | 0.80 | MAPK1 (0.54) | ALDH1A1MAPTPLGPLAUPLAT | |
| SCHEMBL14676017 | 0.80 | SLC1A3 (0.49) | ALDH1A1POLBPLGPLAUPLAT | |
| SCHEMBL14675954 | 0.77 | PLG (0.56) | LMNAALDH1A1MAPTPLGPLAU | |
| SCHEMBL10402270 | 0.76 | BCAT1 (0.50) | LMNAALDH1A1MAPTSMN1; SMN2PLG | |
| SCHEMBL4616119 | 0.75 | LMNA (0.57) | LMNAALDH1A1POLBSLC12A2SLC12A5 | |
| SCHEMBL4617968 | 0.74 | LMNA (0.53) | LMNAALDH1A1POLBSLC12A2SLC12A5 | |
| SCHEMBL4636851 | 0.74 | ALDH1A1 (0.43) | LMNAALDH1A1POLBSLC12A2SLC12A5 | |
| SCHEMBL4617963 | 0.74 | LMNA (0.47) | LMNAALDH1A1POLBSLC12A2SLC12A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |