Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 7/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | PRKCG | P05129 | 2/20 | 0.36 |
| ▸ | PRKCB | P05771 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | PRKCH | P24723 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 2/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11611467 | 1.00 | ALDH1A1 (0.69) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL11615684 | 1.00 | ALDH1A1 (0.69) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL1463562 | 1.00 | ALDH1A1 (0.69) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL28284618 | 1.00 | ALDH1A1 (0.69) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL1803193 | 1.00 | ALDH1A1 (0.69) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL11694128 | 1.00 | ALDH1A1 (0.69) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL28042954 | 1.00 | ALDH1A1 (0.69) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL18092763 | 0.98 | ALDH1A1 (0.67) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL15301129 | 0.98 | ALDH1A1 (0.67) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 | |
| SCHEMBL2811229 | 0.98 | ALDH1A1 (0.67) | ALDH1A1EPHX1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3966647-A | PHENYLETHYL ALCOHOL | LEVER BROTHERS COMPANY (US) | 1976-06-29 | — | — | US | claimed |
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| EP-1885694-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| US-7320972-B2 | 4-Biarylyl-1-phenylazetidin-2-ones | MICROBIA, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1832576-A1 | 4-Biarylyl-1-phenolyzetidin-2-ones | Microbia Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1682499-B1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA INC (US) | 2007-08-08 | — | — | EP | disclosed |
| CN-1902169-A | 4-biaryl-1-phenylazetidin-2-ones | MICROBIA INC (US) | 2007-01-24 | — | — | CN | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| EP-1682499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050209165-A1 | 4-Biarylyl-1-phenylazetidin-2-ones | IRONWOOD PHARMACEUTICALS, INC. | 2005-09-22 | — | — | US | disclosed |
| WO-2005047248-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2005-05-26 | — | — | WO | disclosed |
| US-4124541-A | Dioxa bicyclo dodecane and -hexadecane perfume compositions | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1978-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | APOB, CYP46A1, PCSK9 | ALDH1A1 848/4885EPHX1 3071/4885CHRM2 4264/4885 |
| US-20050209165-A1 | 4-Biarylyl-1-phenylazetidin-2-ones | APOB, CYP46A1, PCSK9 | ALDH1A1 848/4885EPHX1 3071/4885CHRM2 4264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.