Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638749 | 0.94 | SFRP1 (0.66) | ALDH1A1MAPK1SFRP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL4618056 | 0.90 | ALDH1A1 (0.67) | ALDH1A1MAPK1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL4619595 | 0.90 | ALDH1A1 (0.67) | ALDH1A1MAPK1L3MBTL1HPGDHSD17B10 | |
| SCHEMBL4616478 | 0.90 | SFRP1 (0.66) | ALDH1A1MAPK1SFRP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL4616479 | 0.88 | SFRP1 (0.74) | ALDH1A1MAPK1SFRP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6103833 | 0.87 | KMT2A (0.59) | ALDH1A1MAPK1SFRP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL4616589 | 0.86 | SMN1; SMN2 (0.69) | ALDH1A1MAPK1SFRP1SMN1; SMN2KMT2A | |
| SCHEMBL4618073 | 0.86 | ALDH1A1 (0.62) | ALDH1A1MAPK1SFRP1MEN1KMT2A | |
| SCHEMBL4617493 | 0.84 | SFRP1 (0.78) | ALDH1A1SFRP1L3MBTL1SMN1; SMN2CYP3A4 | |
| SCHEMBL4636995 | 0.84 | CYP3A4 (0.67) | ALDH1A1MAPK1SFRP1L3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | ALDH1A1 1865/4885MAPK1 934/4885SFRP1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.