Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619399 | 1.00 | SLC18A3 (0.46) | SLC18A3POLBMAPK1PTPN2PTPN1 | |
| SCHEMBL27731989 | 0.85 | DGAT1 (0.47) | SLC18A3POLBPTPN2PTPN1MAPT | |
| SCHEMBL1066991 | 0.80 | SLC18A3 (0.57) | SLC18A3POLBMAPTALDH1A1NAMPT | |
| SCHEMBL15911925 | 0.80 | SLC18A3 (0.57) | SLC18A3POLBMAPTALDH1A1NAMPT | |
| SCHEMBL4558845 | 0.80 | ESR2 (0.55) | CYP2C9 | |
| SCHEMBL5246202 | 0.80 | ESR2 (0.55) | CYP2C9 | |
| SCHEMBL9474246 | 0.78 | SLC18A3 (0.40) | SLC18A3PTPN2PTPN1CYP2C9NPC1 | |
| SCHEMBL27598297 | 0.78 | CYP2C9 (0.41) | SLC18A3MAPTALDH1A1SMN1; SMN2CYP2C9 | |
| SCHEMBL5438599 | 0.78 | ALDH1A1 (0.45) | SLC18A3MAPTALDH1A1CYP2C9NPC1 | |
| SCHEMBL28002067 | 0.78 | HSD17B1 (0.45) | SLC18A3MAPTSMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893592-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134317-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |